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The most consequential is serotonin syndrome, a potentially fatal hyperserotonergic state resulting from irreversible monoamine oxidase A inhibition, which can be triggered when methylene blue is combined with selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, many opioids, or dextromethorphan

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When Becton Dickinson introduced their BD Ultra-Fine™ 6 mm needle, they reported that 80% of patients preferred the shorter needles over the 8 mm and 12.7 mm alternatives