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Specific genetic variants affect how the body metabolizes alcohol and drugs, how strongly the reward system responds to substances, and how vulnerable a person is to the cognitive disruption that drives compulsive use

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Chronic neuroinflammation—mediated by activated microglia and astrocytes—exacerbates neuronal injury through the release of pro-inflammatory cytokines such as TNF-α and IL-1β (Singh et al., 2019)