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It is important to note that increased IL-4 levels opposite to decreased INF-γ reverse the helper T cell subsets, from cytotoxic Th1 cells to Th2 cells [131]

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To resolve the phylogenetic relationship of TyrA orthologs from divergent organisms including plants and microbes, here we performed structure-guided phylogenetic analyses using PROMALS3D to achieve alignment of TyrA orthologs with low sequence similarities (see section Materials and Methods