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Within each fold, models were fitted on four subsets and evaluated on the held-out subset, yielding mean metrics across folds: Accuracy (fraction correctly classified), AUROC, AUPRC, Specificity (true negative rate), Precision(proportion of positive predictions that are correct), and Recall (proportion of actual positives that are correctly identified)
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Future integration of single-cell metabolomics with advanced strategies like nanocarrier-based delivery and metabolic-immunotherapy combinations is crucial to reverse the pro-tumorigenic properties of the microenvironment and advance clinical translation
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