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Hydrochlorothiazide was not genotoxic in in vitro assays using strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 of Salmonella typhimurium (the Ames test), in the Chinese hamster ovary (CHO) test for chromosomal aberrations, or in in vivo assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene
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Non-heparin anticoagulants, such as direct thrombin inhibitors (bivalirudin, argatroban), indirect (antithrombin-dependent) factor Xa inhibitors (fondaparinux, danaparoid), and direct oral factor Xa inhibitors (rivaroxaban, apixaban), at their therapeutic anticoagulant dosage may be considered (130)