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Although dopamine levels are kept within appropriate ranges through various mechanisms, they can be disrupted by multiple factors, including external psychostimulants such as cocaine and methamphetamine

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It should be also noted that positive effects of vitamin B12 on the recovery of the motor and sensory function and nerve regeneration, especially myelination, could also be shown for a new local application, namely, an electrospun nanofiber sheet incorporating methylcobalamin with local delivery [59]