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Furthermore, we found that chronic hypoxia enhanced ceramide catabolism by inducing hypoxia-inducible factor (HIF)-2α and HIF-2α-dependent transcriptional activation of alkaline ceramidase 2 (Acer2)

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It has also been shown that coronavirus infection can inhibit the activity of numerous karyopherin-dependent host transcription factors including the vitamin D receptor (VDR) and hypoxia-inducible factor α2 [HIFα2]-Epas, p53 in human lung cells [109]