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We will later discuss a large, randomized, double-blind, placebo-controlled clinical trial called the vitamin D and omega 3 trial (VITAL) trial, where vitamin D 2000 IU daily supplementation was associated with a 22% reduction in the development of autoimmune disease (HR 0.78 [95% CI: 0.61, 0.99], p=0.05) ( Viral triggers, particularly Epstein-Barr Virus (EBV), have also been associated with SLE development (116)