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To circumvent this bottleneck, the same group ingeniously exploited the structural similarity between fluorouridine (Fdu) and thymidine, incorporating Fdu during solid-phase synthesis to enable subsequent TME-responsive carbonate linkage with a synergistic PROTAC, yielding AS-2F-NP (Fig

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German J., Smilowitz J., and Zivkovic A., “Lipoproteins: When Size Really Matters,” Current Opinion in Colloid & Interface Science 11 (2006): 171–183