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Telomere attrition contributes to age-associated decline in stem cell function, and age-related telomere shortening has been detected in human CD34 + hematopoietic stem and progenitor cells (Von Figura et al., 2009)

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Our results reveal early metabolomic dysfunction in the motor cortex of prpTDP-43 A315T mice and begin to suggest that reestablishing the perturbed balance may help UMNs regain their health and stability