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Figure 4 Inflammatory stressors (e.g., IL-1Ξ², TNF-Ξ±) and mechanical injury disrupt mitophagy through multiple signaling nodes, among which dysfunction of the PTEN-induced putative kinase 1 (PINK1)βParkin RBR E3 ubiquitin protein ligase (Parkin)pathway is particularly prominent
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Other non-mitochondrial sources of free radicals are the nitric oxide synthase reaction and cytochrome P450 system, among others [12]