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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines

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LC-derived NE also stimulates sympathetic preganglion nerve terminals synapsing with chromaffin cells of the adrenal medulla to release acetyl choline, which in turn activates nicotinic receptors on the medulla, resulting in epinephrine and norepinephrine secretion (127, 128)