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Systemic effects are rare in user reports but are not well characterized in published trials

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A study of medical data from 17,010 participants, 67% of whom were men, between the years 2000 and 2014 revealed significant differences between the four quartiles of homocysteine concentrations and estimated glomerular filtration rate (eGFR)—the greater the homocysteine concentration, the lower the eGFR (p 0.0001) [13]