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Seventy-nine of 99 patients were excluded from the study: 13 because they did not take the clomiphene as prescribed, 51 did not have documented IGF-1 levels prior to and after taking clomiphene, 4 had IGF-1 measured by a method other than liquid chromatography-mass spectroscopy (LC-MS), 6 patients who had a diagnosis of acromegaly, and 5 patients who did not have IGF-1 levels collected within 12 months before and within 24 months after clomiphene treatment (Fig