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However, most therapeutic guidelines suggest that the general population consumes a diet emphasizing antioxidant-rich fruits and vegetables and whole grains.[46] From the literature review we may conclude that the diets high in antioxidants (fruits and vegetables) are capable of reducing blood pressure and cardiovascular diseases, but this is not the case for diet supplementations.[56,57,58,59] The possible explanation is that, in the diet, there is a mix of antioxidants and it is well recognized that they work as a continuous chain, while supplementation is usually given using one or two substances

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Individual Factors Influencing Optimal Glutathione Dosage Baseline glutathione levels, antioxidant enzyme capacity, age, and genetic variations in phase II detoxification genes influence how much glutathione an individual can metabolize effectively