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Both CBD and CBG suppress NF-κB activation and cytokine release, but their combined administration does not exceed the expected sum of their effects ( At the receptor level, co-activation of CB1 and CB2 by THC, alongside CBD-mediated modulation of TRPV1 and GPR55 antagonism, produces convergent signaling that enhances anti-proliferative and anti-angiogenic responses (Moreno et al., 2014