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Its levels increase during inflammation and initiate coagulation mechanisms when vascular injury occurs

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AKR1B1 AKR1B1 (or aldose reductase) is a member of the AKR superfamily, which comprises multiple enzymes involved in oxidoreduction of endogenous and exogenous compounds, including aliphatic and aromatic aldehydes, monosaccharides, steroids, aromatic hydrocarbons (PAHs), or isoflavonoids, using NADH or NADPH as cofactors