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Furthermore, in the high concentration of glutamate-induced neurotoxicity model, infusion of 6 mM L-lactate can obviously reduce the rat cortex lesion from 6.05 ± 0.64 mm 3 to 4.16 ± 0.43 mm 3

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From our data it is unclear as to whether HIV-1 Tat directly promotes neuronal oxidative stress or whether it is an indirect promotion through activation of inflammatory responses via expression of NO, creating a feed forward cycle