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We are also grateful for the contributions of the independent members of the trial oversight committees (Professors Michael Nicholson, Lorna Marson, Colin Wilson, Gabriel Oniscu, Nizam Mamode, Dr Nicholas Torpey, Dr Virginia Chiocchia, and Mr Steve Rogers), and for the support of the Oxford Transplant Centre (Oxford University Hospitals NHS Foundation Trust)

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Since oxidative and nitrosative stress in APAP hepatotoxicity have been known to induce DNA damage and mitochondrial dysfunction 50 , we next examined the phosphorylation of histone H2AX (pH2AX), a hallmark of double-strand breaks (DSBs), in hepatocytes obtained from Peli3 +/+ WT and Peli3 −/− KO mice upon APAP treatment