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DNA demethylation can occur through the substitution of TET enzyme byproducts, 5fC and 5caC, with cytosine via replication-dependent dilution (passive demethylation) or through active demethylation facilitated by thymine DNA glycosylase (TDG) and base excision repair (BER) processes (Aanniz et al

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The diversity of individual dermal compartments in human skin is constituted by the differential expression of Wnt/β-catenin pathway genes (such as Wnt5a,Lef1,Tcf4,and DKK1) between the upper and lower layers of the dermis (132)