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Overexpression of fumarase or PRODH2 increases mitochondrial mass and enhances OXPHOS, promoting memory formation and sustained cytokine production 200,201

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Multidrug resistance transporters also contribute to DOX deprivation in cancers including bladder cancer, esophageal squamous cell carcinoma, or breast cancer, by overexpression of MRP2 (cMOAT or ABCC2) and are mainly responsible for its efflux [378–380]