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14 , 15 As another example, a literature review prior to 1990, had it been performed, would have revealed that the presumed safety of acetaminophen for pediatric use was based solely on studies monitoring liver function, 16 but studies in the 1980s had demonstrated that even lethal doses of acetaminophen do not cause significant liver damage in neonatal laboratory mice 17 or in domestic cats, 13 which have limitations affecting acetaminophen metabolism similar to those found in human neonates

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The long-term efficacy of glutathione is still up for debate, and there are reports of rashes in some individuals using the oral form