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77,102,103 Despite the development of various approaches to increase neurite outgrowth for targeted reinnervation, these strategies might result in the innervation of aberrant targets and/or only attain sub-centimeter scale growth, thus insufficient to reach what would be required in the human brain (i.e., substantia nigra to striatum is at least 3 cm)

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For instance, although PLGA has been approved by United States-Food and Drug Administration (US-FDA) for biomedical and pharmaceutical applications, the use of PLGA NPs for pulmonary administration is not optional due to its acidic products and its slow degradation which results to an airway inflammatory response

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