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Results and discussion Condition screening for the direct formation of 5HP2Os on amino-modified oligonucleotides In the reported 5HP2O synthetic process 30 , a substituted furan is photo-oxidised in the presence of singlet oxygen and methylene blue (MB) in methanol, followed by a reduction with dimethylsulfide (DMS)

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Indeed, patients with pre-existing neuropathy (related to diabetes, alcohol or even idiopathic) developed severe neuropathy after receiving taxane-based chemotherapy (Rowinsky et al., 1993