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There are multiple scientific studies showing that Borrelia can persist after standard courses of antibiotics [220,221,222], including inside the joints [223,224], ligaments [225], fibroblasts [46,84], intracellular compartment [44], endothelial cells [82], skin [226,227], eyes [228], and central nervous system [229,230], with recent studies implying a role for microbial biofilms in Lyme neuroborreliosis [91]