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In HG-induced rat renal tubular epithelial cells (NRK52E) and STZ-induced SD rat models, inositol treatment increased mitophagy through the PINK1/Parkin pathway, while up-regulating the Nrf2/SIRT1/PGC-1α axis enhanced mitochondrial biogenesis in renal tissues of diabetic rats, resulting in a certain nephroprotective effect [148]