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LGM2605 treatment significantly mitigated asbestos-induced cytotoxicity, inflammation, and oxidative damage by reducing ROS generation and nitrosative stress, decreasing levels of MDA and 8-iso Prostaglandin F2α (8-isoP) (markers of lipid peroxidation), enhancing Nrf2 activation and the expression of phase II antioxidant enzymes, HO-1 and Nqo1, as well as reducing levels of IL-1β, IL-18, IL-6, and TNFα in both WT and Nrf2 −/− murine peritoneal macrophages, supporting its possible use as a chemoprevention agent in the development of asbestos-induced malignant mesothelioma [74,75]

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Weight:400GM (40 Servings)

10.1523/JNEUROSCI.4589-10.2011 J