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It is notable that salinity appears to be among the most decisive factors for the diversity and composition of the GM: Indeed, in chinook salmon (Zhao et al., 2020a), salinity was reportedly more important than water temperature with regards to the effect on GM, and in Atlantic salmon the shift from freshwater to saltwater significantly impacted the GM while diet did not show significant associations with the microbiota (Rudi et al., 2018)

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It has been reported that tumor cells induce the production of a specific B cell population called CD25 + B220 + regulatory B cells (Bregs)