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When large doses are ingested, however, the sulfate and glucuronide cofactors (PAPS and UDPGA) become depleted, resulting in more of the paracetamol being metabolized to the reactive intermediate.35–37 As long as GSH is available, most of the reactive intermediate can be detoxified

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Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment