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Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases | Science's STKE

This robust activity contributes to recreational drug use and facilitates the onset of addictive behaviors [15]

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Although these conclusions appeared to be justified based on the reported experiments, it again raised the issue of questionable neutropenia experiments111,115, and the findings contradicted previous data showing that IL-1 receptor-deficient mice were not protected123, that total elimination of Kupffer cells actually enhanced APAP-induced liver injury125,126, and that TLR9120,121 and TLR3127 are important for the pathophysiology

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