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This, however, may reflect the central role of insulin resistance and hyperinsulinemia in the pathogenesis of the different manifestations, rather than a direct linkage of the associated traits

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7 Limitations and challenges Most recent studies on ferroptosis in ophthalmology have focused on RPECs or RGCs, but studies on the ability of Müller cells, vascular endothelial cells, PRs, and even corneal endothelial cells to induce ferroptosis are lacking, and comprehensive single-cell maps are lacking, leaving unresolved questions like the variations in the susceptibility of various cell types to ferroptosis, which can be parallel or mutually causal with apoptosis, necrosis, and pyroptosis (414)