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FIGURE 1 2.2 Inhibition of HER2 The well-established EGF family comprises four members, discovered in sequential order: EGFR, also known as human epidermal growth factor receptor 1 (HER1, ERBB1), human epidermal growth factor receptor 2 (HER2, ERBB2), human epidermal growth factor receptor 3 (HER3, ERBB3), and human epidermal growth factor receptor 4 (HER4, ERBB4) (Kwapiszewski et al., 2016)