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In this situation, p62 undergoes aggregation, and the aggregates recruit Dead-Box (DDX6) (an ATP-dependent RNA helicase) and promote its LLPS, and then DDX6 can intensify the formation of p62 aggregates and facilitate their transformation into p62-dependent p-bodies (pd-pBs) which act as a platform to recruit the inflammasome structure APC and nucleate, ultimately recruiting other structures NLRP6 and its caspase-1 and nucleating again to form mature inflammasomes (Fig