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The dopamine in this pathway speaks to the subcortical brain areas responsible for initiating movement, therefore a lack of dopamine causes PD patients to have rigidity or “akinesia.” A popular treatment for PD, L-dopa, is a precursor to dopamine, and helps make up for lost dopamine neurons

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R., et al., “Aquaporin 1 Confers Apoptosis Resistance in Pulmonary Arterial Smooth Muscle Cells from the SU5416 Hypoxia Rat Model,” Physiological Reports 12, no