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5.4.1 CRISPR/dCas9-based methylation manipulation Innovative studies utilizing CRISPR/dCas9-TET1 systems for targeted DNA demethylation have provided direct evidence for the causal role of DNA methylation in EED-induced reproductive dysfunction

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We treated cells with both iHAP1 [16], a PP2A agonist, and LB-100 [17], an inhibitor of PP2A, and showed that iHAP1 mediated the activation of PP2A mitigated hypoxia-induced neuronal death (Supplemental Fig