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Performance metrics should include: Clinical evidence of brightening efficacy (tyrosinase inhibition studies) Tolerance data from repeat insult patch testing Minimum erythema dose documentation for photosensitivity risk assessment Accelerated stability studies demonstrating 24-month shelf life Cost-efficiency extends beyond unit pricing

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Both groups had a balanced distribution of Fitzpatrick skin types 4 and 5, where type 4 was observed among 15 (75%), and type 5 was observed among the remaining 5 (25%) in each group