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The metagenomic perturbations characteristic of CKD—manifesting as attenuated microbial biodiversity, compromised fermentative functionality, and deteriorated epithelial barrier architecture—precipitate a deleterious cascade whereby intestinal dysbiosis perpetuates and amplifies the uremic milieu through enhanced nephrotoxin biosynthesis and systemic pro-inflammatory signaling

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Keywords: histamine, brain, mast cells, microglia, neurodevelopment, neuroinflammation, astrocytes, neurodevelopmental disorders Introduction Histamine is a biogenic monoamine as well as an endogenous neurotransmitter with a diverse array of physiological functions, ranging from local inflammatory responses to regulating synaptic transmission in the brain