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Conversely, the chemogenetic inhibition of LH GABAergic neurons potentiates the anorexigenic effects of tesofensine ( Fig 6 )

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Note, for BPC 157, a persistent effect is mandatory, as it can prevent amphetamine disturbances, reverse already advanced disturbances, and counteract amphetamine “reverse tolerance” even after a very long period (i.e., 46 days) [70,153] and even substitute the loss of dopamine neurons (MPTP) (note, BPC 157 counteracted tremor, rigor, akinesia, and also MPTP-mortality) [69]