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In addition, loss of glutathione peroxidase 4 (GPX4), a central regulator of ferroptosis, leads to hemolytic anemia and increases spleen erythroid progenitor death through receptor-interacting protein 3 (RIP3)-dependent necroptosis signaling 48

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Research has explored its role in cellular growth signaling, differentiation pathways, and IGF-1 receptor interaction mechanisms in laboratory models