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Aside from hyperhomocysteinemia, C677T or A1298C MTHFR (the two genes most studied) mutations are associated with an increased risk of other conditions including cardiovascular and thromboembolic diseases such as strokes, blood clots, and heart attacks, ADHD in children, pregnancies with neural tube defects, depression, anxiety, diabetic neuropathy, glaucoma migraines, schizophrenia, and colorectal polyps

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While we don’t have specific studies looking at the use of expired semaglutide, it’s generally accepted that expired medications become less effective over time