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For example, genotype A presents a higher activation of Nrf2/ARE pathway than genotype G [263]

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In 2012, a study revealed that NAC treatment reversed lysyl oxidase activity to normal levels and increased GSH levels in the lung of bleomycin-induced rats, inhibiting TGF-β1 and α-SMA expression, thus attenuating pulmonary fibrosis (Li et al., 2012)