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Calcinosis universalis (the abundant subcutaneous calcifications seen in rare juvenile dermatomyositis patients) should not be confused with myositis ossificans, a rare disease associated with skeletal deformities, such as short great toe or curved fingers
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"If this approach works in humans, it will really change the conversation that providers have with patients," Scadden said, especially for those "who have these underlying genetic disorders and for who the new gene-editing and gene therapy techniques are being developed." The scientists are now trying to identify antibodies that would be effective in humans, and a company has been formed to move the work towards translation and determine which models are most useful in a preclinical setting
