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Probiotics repair and fortify these multilayered barriers through multi-target, synergistic mechanisms, and their effects are highly strain-specific ( Prioritizing the chemical and immune barriers, Lactobacillus plantarum HNU082 increases short-chain fatty acid (SCFA) levels, which stimulate goblet cells to secrete MUC2, strengthening the chemical barrier, and reestablishes immune homeostasis by inhibiting NF-κB and bidirectionally modulating cytokine production (Wu et al., 2022
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