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administered a single oral dose of up to 3 g of GSH to seven healthy subjects and did not observe an increase in blood GSH levels, concluding “it is not feasible to increase circulating GSH to a clinically beneficial extent by the oral administration of 3 g of GSH.” 22 Yet three studies have evaluated the impact of reduced GSH supplementation combined with oxidative chemotherapeutic agents in patients with various cancers 23–25