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A systematic review in Addictive Behaviors found that 15 to 20% of patients stopping long-term SSRI therapy experience clinically significant discontinuation effects

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However, other reports indicate that the absence of p21 or p16 can exacerbate kidney injury in the short term [34, 35], suggesting that senescence may also play an important, if transient, protective role in tissue repair, depending on the disease context and timepoint examined [36]