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The overexpression of miR-21-3p correlates with the inhibition of critical neuronal and synaptic genes such as DLGAP1 , which decreased the expression of Protocadherin-19 ( PCDH19 ), associated with cognitive impairment

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Estrogen therapy is known to have a protective role against neurodevelopmental disorders and glutamate-induced neurotoxicity via the mTOR pathway [125]