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The prosurvival effect involved the antiapoptotic Bcl-2 proteins, and the activation of transcription factors cAMP response element binding protein (CREB) and nuclear factor-kappa B (NF-κB), upstream effectors of the antiapoptotic Bcl-2 protein expression, as well as antiapoptotic protein kinase C (PKC)α/β, a posttranslational activator of Bcl-2 [57]

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This reduces the load on the gut at any one time and can ease cramping and urgency

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