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Reduced methylation due to functional B12 deficiency results in depression, anxiety and poor sleep - common symptoms in CFS Reduced methylation due to functional B12 deficiency, results in lower production of melatonin and poor maturation of the gut Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyalitis (ME) is an ill defined disease that is characterized by a post exercise tiredness or malaise

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The human evidence consists of: A small number of case reports and case series One Phase II clinical trial for inflammatory bowel disease (not a musculoskeletal indication) that was conducted in the early 2000s and showed some safety signal data but was not completed Anecdotal reports from athletes and patients who have used the compound The absence of human randomized controlled trial data is a critical limitation