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The scientists found that the mice not receiving vitamin E exhibited evidence of oxidative injury to their kidneys and testis, whereas those organs appeared normal in mice receiving vitamin E

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As creatine kinase catalyses a reaction close to equilibrium, the only way in which phosphocreatine and ATP can remain unchanged, while total creatine is reduced, would be if there is an increase in free ADP or a decrease in pH, according to the following equation: As noted above, it is possible that altered creatine concentration could be related to secondary mitochondrial dysfunction postulated to be involved in the pathophysiology of CFS (Maes and Twisk 2010)