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Dark state and active forms of T94 2.61 I/E134 3.49 Q/M257 6.40 Y triple mutant were modeled by mutating the residues with PyMol v1.7 (dark-state 3 M, active 3 M), respectively 44

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TB-500 shows comparable room temperature tolerance in lyophilized form, lasting 2-3 weeks under typical conditions